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management differential signs hematology lupus sle systemic vasculitis activation apml arthritis autoimmune behcet classification complexes congenital differentiation disease endocarditis esophageal
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... Non-autoimmune rheumatologic ... Induced Lupus: • Symptoms ... and leukemia • Lung ... #Diagnosis #Rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
effusion, Restrictive lung ... Demyelinating syndromes ... SLE #systemic #erythematosus ... #signs #symptoms ... #diagnosis #rheumatology
Streptococcal Toxic Shock Syndrome (STSS) Complication of invasive GAS disease characterized by shock & MOF → occurs
Streptococcal Toxic Shock Syndrome ... kidneys, liver, lung ... coagulopathy, erythematous ... macular rash, soft ... #STSS #treatment
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Systemic lupus erythematosus ... rash) • Heart, lung ... Treatment: • Corticosteroids ... #Diagnosis #Management ... #Hematology #Rheumatology
Congenital Long QT Syndrome: Illness Script Who? - Kids or young adults, usually < 30 - high
QT Syndrome: Illness ... live births Symptoms ... arrest/death - Symptoms ... family history) Treatment ... #Diagnosis #Cardiology
Hepatopulmonary Syndrome - Diagnosis and Management Summary A defect in arterial oxygenation due to a gas exchange
Hepatopulmonary Syndrome ... absence of intrinsic lung ... intrapulmonary vascular ... on radioactive lung ... resolution of symptoms
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... Cathepsin G release → vascular ... : >3 symptoms, or ... Renal Failure Treatment
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
meningitis), MCC CNS symptoms ... and diplopia) • Vascular ... Arthritis, AS Treatment ... #signs #symptoms ... #rheumatology #
Rheumatoid Arthritis - Signs and Symptoms • Ocular: Keratoconjunctivitis sicca, Episcleritis, Scleritis, Scleromalacia perforans • Pulmonary:
Arthritis - Signs and Symptoms ... Pulmonary: Parenchymal lung ... Rheumatoid nodules, Vascular ... Thrombocytosis, Felty's syndrome ... #diagnosis #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
ischemia - Skin: erythematous ... and bullous or vesicular ... systemic lupus erythematosus ... Presentation - Systemic Symptoms ... #rheumatology #
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