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diagnosis pharmacology binders comparison management nephrology syndrome table hyperkalemia phosphate potassium differential disadvantages hypophosphatemia lysis oncology sideeffects tumor tumorlysis workup
Veltassa (Patiromer) MECHANISM: Potassium Binder INDICATION: Treatment of Hyperkalemia FORMULATION: Powder for oral suspension DOSING: 8.4
Veltassa (Patiromer ... least 3 hours Veltassa ... Veltassa can be ... /ambcarerx #Veltassa ... #KBinder #Hyperkalemia
Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS Laboratory TLS: • Uric
Lysis Syndrome (TLS ... Abnormalities of TLS ... Laboratory TLS ... 6.0 mEq/dL • Phosphorus ... mg/dL Clinical TLS
Pathophysiology of Tumor Lysis Syndrome (TLS) Tumor Cell Lysis -> Release of DNA • Purines -> Hypoxanthine /
Lysis Syndrome (TLS ... excretion) • Phosphorus ... TumorLysis #Syndrome #TLS
Tumor Lysis Syndrome - Workup and Management Initial workup: BMP, Serum uric acid, LDH, Urine output, Consider
≥ 6 mEq/L • Phosphorus ... Treatment of Clinical TLS ... MatthewHoMD #TLS
Potassium Binders for Management of Hyperkalemia • SPS - Sodium polystyrene sulfonate • Patiromer (veltassa) •
Potassium Binders ... • Patiromer (veltassa ... cyclosilicate #Potassium #Binders
Phosphate Binders #Pharmacology #Nephro #Phosphate #Phosphorus #Binders #Comparison #Table #Disadvantages #SideEffects
Phosphate Binders ... Nephro #Phosphate #Phosphorus ... #Binders #Comparison
Hypophosphatemia - Differential Diagnosis Algorithm Appropriately Low Kidney Phosphate Excretion: • Decreased GI Absorption: Chronic Diarrhea, Antacids,
Antacids, Phosphate Binders ... Algorithm #nephrology #phosphorus
Workup for Hypophosphatemia - Differential Diagnosis Framework Rule out spurious hypophosphatemia: paraproteinemia, acute leukemia Measure Urine Fractional Excretion
absorption (Antacids, Phosphorus ... binders, Niacin
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
leukapheresis - TLS ... Non calcium phos binders ... Lysis #Syndrome #TLS
Potassium-Binding Agents to Treat Hyperkalemia Sodium zirconium cyclosilicate (Lokelma): • Mechanism: Preferentially captures K in exchange for
hypokalemia Patiromer (Veltassa ... table #comparison #binders
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