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causes management oncology bleeding intravascular product workup classification coagulation dic disseminated extravascular hemolysis hemostasis hodgkins lymphoma mds myelodysplasia myelodysplastic nonpalpable
Thrombocytosis - Differential Diagnosis Platelet Count > 450 Reactive: • Anemia/blood loss (Fe deficiency) • Infection/Sepsis • Non-infectious
Differential Diagnosis ... Platelet Count ... /blood loss (Fe ... deficiency) • ... #Platelets #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
- Elevated Platelet ... → Refer to hematology ... , deficiency anemia ... #Platelets #Differential ... #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
RBC's secondary to platelet ... • Platelet defects ... : Platelet Defects ... Diagnosis #hematology ... #rheumatology #
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Diagnosis Algorithm ... Thrombocytopenia ... Sequestration Disordered Platelet ... Diagnosis #Algorithm ... #Causes #Hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Diagnosis Algorithm ... Chronic Myelogenous Leukemia ... anemia #Thrombocytosis ... Diagnosis #Algorithm ... #Causes #Hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Diagnosis Algorithm ... with or without platelet ... #Anemia #Differential ... #workup #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
microangiopathy: Thrombotic thrombocytopenic ... purpura (TTP), ... G6PD deficiency) ... Extravascular #Causes #differential ... #diagnosis #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
Purpura Activity ... hallmark for the disease ... Platelet count ... and decreased platelet ... #Workup #Hematology
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Diagnosis Algorithm ... hemostasis: - Thrombocytopenia ... - Abnormal platelet ... Diagnosis #Algorithm ... #Causes #dermatology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
maculopapular rash ... transfusion, due to anti-platelet ... common following platelet ... contamination: Platelets ... #management #hematology
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