15 results
Localization of Renal Tubular Defects
Fanconi Syndrome: Proximal tubule
Bartter Syndrome: Thick ascending loop of Henle
Gitelman Syndrome: Distal
Localization of Renal ... Proximal tubule Bartter ... : Distal convoluted ... #Pathophysiology ... #Nephrology
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
Diagnosis Algorithm ... : Proximal and distal ... thiazide diuretics, Bartter ... Algorithm #causes #potassium ... #low #nephrology
Hypokalemia - Differential Diagnosis Algorithm

Transcellular Shift:
 • Alkalosis
 • ↑ beta-2 adrenergic simulation 
 • Erythropoiesis
Diagnosis Algorithm ... Transcellular Shift: • Alkalosis ... • Refeeding syndrome ... #Algorithm #nephrology ... #low #potassium
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
suggests extra-renal ... - Metabolic Alkalosis ... Emesis, Diuretics, Bartter ... #diagnosis #Algorithm ... #nephrology #low
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
of cells on the distal ... (renal potassium ... • Bartter syndrome ... #diagnosis #nephrology ... #management #pathophysiology
Causes of Hypokalemia - Differential Diagnosis Algorithm
Defining the cause of hypokalemia starts by measuring urinary K
- Differential Diagnosis ... • Renal tubular ... • Diuretics, Bartter's ... algorithm #causes #nephrology ... #potassium
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine
Urine K+
Non-reabsorbable anion effect ... Mg2+ deficiency, Bartter ... syndrome #hypokalemia ... differential #algorithm #diagnosis ... #nephrology
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Pathophysiology ... H+ secretion → Hypokalemia ... Metabolic alkalosis ... #Pathophysiology ... #nephrology #diagnosis
Causes of Metabolic Alkalosis: Differential Diagnosis
ECF volume contracted: urine chloride concentration <20 meq/L
 • Gastric alkalosis:
: Differential Diagnosis ... tubule diuretic effect ... actively working • Bartter ... other • Severe potassium ... #Causes #nephrology
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
Epithelial Cells Renal ... acid transporter Bartter ... renal tubular acidosis ... #Kidney #Nephrology ... #Diagnosis #Differential