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diagnosis management pharmacology fungal antifungal infections infectiousdiseases differential microbiology treatment antibiotics antibiogram aspergillus betadglucan comparison galactomannan overview review atlas biomarkers
Spectrum of activity for systemic antifungal agents Antifungals: 5FC, flucytosine; AMB, amphotericin B; ANI, anidulafungin; CAS, caspofungin;
posaconazole; VOR, voriconazole ... neoformans, Mucorales, Fusarium
Fusarium Treatment • Antifungal "susceptibility" can vary with Fusarium spp • F. oxysporum: low MICS to
Fusarium Treatment ... can vary with Fusarium ... triazole (e.g., voriconazole ... @ID_fellows #Fusarium
Fusarium Infections Acquired through: 1. Inhalation of airborne conidia > germinates > blood > disseminated 2. Trauma (implantation with
Fusarium Infections ... manifestations of Fusarium ... triazole (e.g., voriconazole ... @ID_fellows #Fusarium
Invasive Aspergillus (IA) - Diagnosis and Management Aspergillus is ubiquitous in nature. Most invasive infections are caused
positive with Histo, Fusarium ... appearance includes: Fusarium ... choice for IA = Voriconazole
Antifungal Azoles - Antibiotics Class Overview Mechanism: inhibit ergosterol synthesis (important component of fungal cell membranes)
Voriconazole(PO ... #Itraconazole #Voriconazole
Invasive fungal infections: Morphology, Risk Factors, Disease Characteristics, Diagnostic Tools, First-Line Treatment Aspergillus, Mucorales, P. Jiroveci, Cryptococcus,
, Coccidiodes, Fusarium
Fungal Biomarkers: Comparing Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi •
Fusarium, Acremonium ... Other Pathogens: Fusarium
Fusarium on Culture and Microscopy Collecting a sample for culture from the eye is never fun, but
Fusarium on Culture ... richdavisphd #Fusarium
Antibiotics and CNS Diffusion 1. Drugs with good CNS diffusion: - Fluoroquinolones, Fluconazole, voriconazole, Rifampin, Oxazolidinones, Metronidazole 2. Drugs
, Fluconazole, voriconazole
Antifungal Agents Frequently Used in Leukemia Antibiogram: • Fluconazole • Itraconazole • Voriconazole • Posaconazole • Caspofungin
Itraconazole • Voriconazole
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