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diagnosis differential hematology causes hemolysis intravascular abnormal ascorbicacid atlas cold color discoloration disease ferritin key mcv morphology nephrology normocytic pathophysiology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... . primary cold agglutin ... • Intrinsic RBC ... G6PD deficiency) ... diagnosis #hematology #anemia
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Diagnosis Algorithm ... elliptocytosis - RBC ... Defects • G6PD deficiency ... • PK deficiency ... anemia •
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Anemias (MAHA) ... • Early Iron ... Deficiency # ... Normocytic #Anemia
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
• Microcytic - Iron-deficiency ... Myelodysplastic syndrome ... spherocytosis, Hemolytic ... , Thalassemia, Iron-deficiency ... uremic syndrome
Iron Deficiency Anemia - Differential Diagnosis Algorithm Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR • Blood loss:
Iron Deficiency ... Anemia - Differential ... ) hemolysis, Intensive ... Gastrectomy, WHDA syndrome ... #Deficiency #Anemia
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
to Anemia - Differential ... inflammation) • Iron ... Sideroblastic anemia ... ACD, Aplastic anemia ... MatthewHoMD #Anemia
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Differential Diagnosis Algorithm ... Agglutination - Cold agglutinins ... #Anemia #Differential ... #Diagnosis #Algorithm
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Syndrome (CAS): ... • Symptoms of anemia ... anemia • Cold ... Blood smear - RBC ... #anemia #hematology
Scurvy (Vitamin C Deficiency) - Diagnosis and Management Vitamin C is required for hydroxylation of proline residues
Diagnosis and Management ... breath, wasting, anemia ... Loss of teeth Anemia ... can lead to iron ... contribute to nonimmune hemolysis
Causes Abnormal Urine Color - Differential Diagnosis Turbid White Urine (Albinuria): • Chyluria, Filariasis, Schistosomiasis, Malignancy, Phosphaturia,
hemolysis (G6PD ... deficiency, sickle ... cell anemia, thalassemia ... Hydroxycobalamin, Ibuprofen, Iron ... Intramuscular iron
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