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differential pruritus rheumatology causes dermatology generalized leukemia lymphocytic secondary workup antibody arthritis atlas bloodcell calculation ckd classification common cvid erythematosus
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell ( ... , Chronic disease ... anemia (sometimes ... #differential #diagnosis ... #hematology #microscopy
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Hemolytic Anemia ... • Anemia: macrocytic ... #Hemolytic #Anemia ... #diagnosis #management ... #treatment #rheumatology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
Index < 2: • Anemia ... kidney disease, ... • Hemolysis: Autoimmune ... Production #Index #hematology ... #diagnosis #calculation
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
5) Symptoms of anemia ... marrow failure with anemia ... #Leukemia #oncology ... #hematology #hemeonc ... #diagnosis #management
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Algorithm - Systemic ... == Blood Glucose ... Creatinine & BUN: • Chronic ... renal failure/uremia ... Hyperthyroidism CBC
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
cells can indicate disease ... • Neutropenia, anemia ... microglobulin Treatment ... #workup #oncology ... #hematology
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Algorithm Blood ... Creatinine & BUN: • Chronic ... renal failure/uremia ... Hyperthyroidism CBC ... Pruritus #secondary #systemic
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
cell count (anemia ... • Aplastic Anemia ... Megaloblastic Anemia ... Myelophthisic Anemia ... #hematology #oncology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to impaired B-cell ... hemolytic anemia ... ) • Systemic granulomatous ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... • Non-autoimmune ... deficiencies • Autoimmune ... lymphopenia, low PLT • Anemia ... with Lupus: • Chronic
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