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diagnosis causes workup algorithm disease hemolytic rheumatology agglutinin approach arthritis atlas autoimmune bandemia bloodcell cbc classification cold disorders elevatedmcv fever
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Warm Antibody Autoimmune ... ↑ LDH • Anti-RBC ... type ± C3d • Blood ... smear: Differential ... Pouchelon #Warm #Antibody
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
- Differential ... Diagnosis Algorithm Blood ... Normochromic RBCs on Smear ... Spherocytes on Smear ... Algorithm #Causes #Hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Volume (MCV) - Differential ... Algorithm Normal Blood ... Smear • Drugs ... Cells, Normal WBCs ... Algorithm #Causes #Hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell ( ... disease, McLeod blood ... #Morphology #differential ... #diagnosis #hematology ... #microscopy #atlas
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Defects: Sickle cell anemia ... - Peripheral Blood ... Smear ↑ abnormal ... #Diagnosis #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Platelet Disorders - Differential ... plateletcount), peripheral blood ... smear, HIV/HCV ... changes), high MCV anemia ... dysplasia on the smear
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
of peripheral blood ... cultures, including blood ... #differential # ... #CBC #hematology ... #pathophysiology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Peripheral Smear ... abnormal under a microscope ... count with differential ... smear • Bone marrow ... Syndromes #diagnosis #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
of Peripheral blood ... smear - Shows schistocytes ... from ischemia WBC ... count and differential ... Diagnosis #Workup #Hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Immunoglobulin M (IgM) • Blood ... smear - RBC agglutination ... younger pts) Differential ... sensitize red blood ... #hematology #diagnosis
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