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diagnosis oncology differential management algorithm anemia causes lymphocytic approach bandemia calculation cancer cbc coagulation dic disseminated gap globulin hemeonc hodgkins
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
cells can indicate disease ... aplasia • ITP ... #CLL #Chronic ... #diagnosis #workup ... #oncology #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... extramedullary disease ... develop leukostasis syndrome ... • Tumor lysis syndrome ... #Hematology #Oncology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Diagnosis Algorithm Blood ... Deficiency • Aplastic ... Disease • Marrow ... Non-lmmune #Anemia #Classification ... Algorithm #Causes #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... for workup, including ... : Acute blood loss ... • Infections: Chronic ... Diagnosis #Algorithm #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
the peripheral blood ... kidney disease, ... marrow failure: Aplastic ... defects (e.g. sickle cell ... Production #Index #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
virus (EBV) • Leukemia ... • ↓ WBC • ↓ ... anemia Treatment ... result from low blood ... Anemia #oncology #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic ... Leukemia (CLL) ... chemotherapy for low-risk disease ... uw_IMresidency #CLL ... #hematology #hemeonc
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Causes • Anemia • Aplastic ... Marrow Failure • Chronic ... Cell Leukemia ... Myeloproliferative Disease ... #diagnosis #hematology
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
of peripheral blood ... Tissue damage • Leukemia ... • Autoimmune diseases ... #CBC #hematology ... #pathophysiology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
promyelocytic leukemia ... ABO incompatible blood ... protein C and S Pathophysiology ... • Severe Liver Disease ... #management #hematology
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