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algorithm management oncology workup dermatology erythematosus lupus classification polycythemia signs chronic generalized hemolysis joint leukemia pain pruritus vasculitis activation agglutinin
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Decreased WBCs ... Hypersplenism • Secondary ... RA, SLE, PRV, Chronic ... #Causes #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... anemia): ... #differential # ... diagnosis #hematology ... #anemia
Causes of Polycythemia (Erythrocytosis) - Differential Diagnosis Algorithm Relative - Normal RBC Mass / Decreased Plasma Volume
(Erythrocytosis ... ) - Differential ... Relative - Normal RBC ... Chronic Chest Symptoms ... #Causes #Hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
PD deficiency, Pulmonary ... uremic syndrome ... Morphology #Atlas #key #diagnosis ... #differential # ... hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Diagnosis Secondary ... malignancies • Anemia ... iron deficiency, hemolysis ... #Diagnosis #Causes ... #hematology #secondary
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... ): SS, SC, SE, Sβ ... #Anemia #Differential ... #workup #hematology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
deficiency • Fanconi’s anemia ... Wiskott-Aldrich syndrome ... : • Systemic lupus ... Antibody-mediated hemolysis ... #Diagnosis #Hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... DIC/TTP/HUS - Hemolytic ... anemia - Splenomegaly ... #Diagnosis #hematology ... #rheumatology #
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Volume (MCV) - Differential ... Diagnosis Algorithm ... Myelodysplastic Syndromes ... #Causes #Hematology
Erythrocytosis - Polycythemia Differential Diagnosis Algorithm Elevated Hemoglobin: • Males: Hb > 16.5 g/dL/HCT ≥ 49% •
Polycythemia Vera Secondary ... Polycythemia - Acquired Causes ... Hypoxia-driven: Cardiac/pulmonary ... disease, Smoking ... #hematology
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