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differential erythematosus sle anemia causes hemolytic oncology systemic diffuse eularacr extravascular intravascular lymphadenopathy monoclonal paraproteinemias slicc testing vasculitides vasculitis workup
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
• Arthritis domain ... least 2 joints • Neurologic ... , Autoimmune hemolysis ... Erythematosus #diagnosis ... #rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... microangiopathy: Thrombotic thrombocytopenic ... usually IgG) (e.g. lupus ... • Intrinsic RBC ... #hematology #anemia
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
• Systemic Lupus ... • Rheumatoid Arthritis ... (Pancytopenia, WBC ... Lymphadenopathy #LAD ... #Hematology #Oncology
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus Clinical and Immunologic Criteria CLINICAL CRITERIA - ACUTE CUTANEOUS LUPUS
SLICC SLE Diagnostic ... SEROSITIS - RENAL - NEUROLOGIC ... - HEMOLYTIC ANEMIA ... (<1000/MM3) - THROMBOCYTOPENIA ... #Rheumatology #
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential Diagnosis ... Algorithm • Sickle ... Schistocytes, thrombocytopenia ... #Algorithm #workup ... #hematology #testing
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Skin Disease Classification ... Differential Diagnosis ... Non-autoimmune rheumatologic ... Malignancy (e.g. hematologic ... #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
such as systemic lupus ... retinopathy Lab ... Tests: • CBC ... #rheumatology # ... classification
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
et diutinum Neurologic ... • Coombs (-) hemolytic ... to cold IgG • Lupus ... Paraproteinemias #Hematology ... #Differential #Diagnosis
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