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diagnosis management anemia causes hemolytic algorithm apml arterial atlas chronic classification cll coagulation dic differentiation disorders disseminated embolism extravascular hemolysis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Causes Intravascular ... microangiopathy: Thrombotic thrombocytopenic ... • Intrinsic RBC ... #Causes #differential ... #diagnosis #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Platelet Disorders - Differential ... Diagnosis and Workup ... or if a primary hematologic ... Diagnosis #Causes #Workup ... #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
infections/fevers • Thrombocytopenia ... Pancytopenia: • ↓ RBC ... • ↓ WBC • ↓ ... #Anemia #oncology ... #hematology #diagnosis
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell (RBC ... Thrombotic idiopathic thrombocytopenia ... , Disseminated intravascular ... key #diagnosis #differential ... #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia - Differential ... Schistocytes, thrombocytopenia ... Hemolytic #Anemia #Differential ... Diagnosis #Algorithm #workup ... #hematology #testing
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... protein C and S Pathophysiology ... hydration • RBC ... #Disseminated #Intravascular ... treatment #management #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
for Thrombotic Thrombocytopenic ... reflection of intravascular ... from ischemia WBC ... count and differential ... #Hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
ATRA treatment Pathophysiology ... if high risk if WBC ... initiation • Differential ... diagnosis #management #hematology ... #oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphocytosis on CBC ... Neutropenia, anemia, thrombocytopenia ... Pure red cell aplasia ... Leukemia #diagnosis #workup ... #oncology #hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Arterial Thrombosis - Differential ... Heparin-induced thrombocytopenia ... - Disseminated intravascular ... Venous #Arterial #pathophysiology ... #hematology #differential
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