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anemia rbc chronic hemolysis key leukemia lymphocytic pathology workup agglutinin algorithm aplastic apml bloodcell bloodsmear causes classification cold common cvid
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
RBC) Morphology ... #Morphology #Atlas ... #key #diagnosis ... #differential # ... hematology
Pathologic Red Blood Cell (RBC) Morphologies and Associated Diseases Acanthocyte (spur cell), Basophilic stippling, Bite cell,
(RBC) Morphologies ... #RedBloodCell #Morphology ... Morphologies #Key #Atlas ... #Microscopy #Pathology ... #Hematology #Diagnosis
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
RBC) Morphology ... Bite Cell RBC: G6PD ... #Morphology #differential ... #diagnosis #hematology ... #microscopy #atlas
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... ) (e.g. lupus, CLL ... • Intrinsic RBC ... Extravascular #Causes #differential ... #diagnosis #hematology
Peripheral blood findings in microangiopathic hemolytic anemia. DIC is a clinical and laboratory diagnosis, not
DIC is a clinical ... and laboratory diagnosis ... , not a morphologic ... #anemia #Hematology ... Pathology #Smear #Microscopy
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential ... Diagnosis Algorithm ... Consider sickle cell ... other reproducible morphologic ... #workup #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Diagnosis Framework ... Drug-associated, PCH, Evans Syndrome ... Defects: Sickle cell ... Diagnosis #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... Diagnosis: • ... Lymphocytosis on CBC ... #workup #oncology ... #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Viral Infection Clinical ... Diagnosis: • hemolytic ... younger pts) Differential ... #anemia #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... • Induce blast cell ... initiation • Differential ... #management #hematology ... #oncology
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