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diagnosis hematology differential workup aplastic causes management apml chronic cll differentiation diffuse elevatedmcv hematololgy lad leukemia lymphadenopathy lymphocytic macrocytic macrocytosis
Aplastic Anemia Summary • Definition • Pathophysiology • DDx: AA vs Hypocellular MDS • Expectation •
Aplastic Anemia ... Definition • Pathophysiology ... Expectation • Rx Algorithm ... #diagnosis #oncology ... #hematololgy
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Differential Diagnosis Algorithm ... Lymphoblastic Leukemia (Pancytopenia ... , WBC differential ... #Causes #Hematology ... #Oncology
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Differential Diagnosis Algorithm ... HLH syndrome 5. ... Acquired Aplastic Anemia ... marrow failure syndrome ... #Hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
bone marrow + pancytopenia ... • Peripheral Pancytopenia ... : • ↓ RBC • ... ↓ WBC • ↓ PLT ... #oncology #hematology
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Differential Diagnosis Algorithm ... HLH syndrome 5 ... Acquired Aplastic Anemia ... marrow failure syndrome ... #Hematology
Hematology Algorithms Anemia is described as a reduction in the proportion of the red blood cells.
Hematology Algorithms ... Pancytopenia is ... The etiology of pancytopenia ... contribute to the pancytopenia ... #Mentzerindex #Pancytopenia
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Differential Diagnosis Algorithm ... Myelodysplastic Syndromes ... Cells, Normal WBCs ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... ATRA treatment Pathophysiology ... if high risk if WBC ... QD until normal WBC ... #oncology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
capillary leak syndrome ... +Organomegaly+↑RBC ... (-) hemolytic anemia ... Paraproteinemias #Hematology ... Differential #Diagnosis #Oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphocytosis on CBC ... • Neutropenia, anemia ... • Richter’s Syndrome ... diagnosis #workup #oncology ... #hematology
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