7 results
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
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Hemolysis - Differential ... Diagnosis Algorithm ... • MAHA (TTP, DIC ... #Differential #Diagnosis ... #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): - Disseminated ... intravascular coagulation ... (DIC) - HELLP ... #Causes #differential ... #diagnosis #hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Disseminated Intravascular ... Coagulation (DIC ... Intravascular #Coagulation ... #diagnosis #causes ... #hematology
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
Differential Diagnosis ... • AIHA: warm, cold ... , drug induced ... #classification ... #hematology
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Differential Diagnosis ... prolonged, there could ... hemorrhage • Disseminated ... intravascularcoagulation (DIC ... hematology #coagulation
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Disseminated intravascular ... coagulation (DIC ... Prolonged #Causes #diagnosis ... #differential # ... hematology #coagulation
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Viral Infection Clinical ... Presentation - Cold-Induced ... Acrocyanosis (Cold-induced ... younger pts) Differential ... hemolytic #anemia #hematology