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hematology management differential chronic cll lymphocytic mds myelodysplastic algorithm anemia apml causes classification dermatology differentiation diffuse erythematosus gap globulin hemeonc
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Diagnosis: • ... aplasia • ITP ... microglobulin Treatment ... #diagnosis #workup ... #oncology #hematology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
- Differential Diagnosis ... (Pancytopenia, WBC ... Non-Hodgkin's Lymphoma ... Reed-Sternberg Cells ... #Oncology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... dys- (abnormal) -plastic ... = funny-shaped cells ... transformation to acute leukemia ... #hematology #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
develop leukostasis syndrome ... • Tumor lysis syndrome ... lymphoma #Leukemia ... #Hematology #Oncology ... #Diagnosis
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
virus (EBV) • Leukemia ... • ↓ WBC • ↓ ... anemia Treatment ... #Anemia #oncology ... #hematology #diagnosis
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
minimal tumor burden Diagnosis ... lymphocytes, smudge cells ... lymphoma (Richter ... #oncology #hematology ... #hemeonc #diagnosis
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Causes • Anemia • Aplastic ... • Hairy Cell Leukemia ... #diagnosis #hematology ... #oncology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
blasts and high WBC ... • Lab values: WBC ... leukapheresis - TLS ... Lysis of tumor cells ... #TLS #diagnosis
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Workup: • Full ... platelets - WBC ... Treatment • Early ... #diagnosis #classification ... #hematology #oncology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... • Induce blast cell ... if high risk if WBC ... #oncology
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