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diagnosis hematology differential management algorithm oncology causes hemolytic sle summary systemic testing approach arthritis atlas chronic cll erythematosus hemolysis intravascular
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Decreased RBC ... Disease • Marrow ... Thalassemia • RBC ... Disorder • RBC ... #Classification
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell (RBC ... Morphology Microcytic RBC ... sometimes) Macrocytic RBC ... Bite Cell RBC: G6PD ... Target Cell RBC
Common RBC Inclusions and Associations • Howell Jolly Bodies: Hyposplenism, Asplenism, Severe hemolytic anemia • Heinz
Common RBC Inclusions ... , Hemolytic anemia ... : Hemoglobin H disease ... Sickle cell, MDS #RBC ... Bodies #diagnosis #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Neutrophils - Low RBC ... • Pancreatic Disease ... RBCs in Rouleaux ... Cells, Normal WBCs ... • Liver Disease
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... hypertension • Unusual RBC ... acanthocytes - Consider RBC ... Diagnosis #Algorithm #workup ... #hematology #testing
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... (MCV): Average RBC ... wide range of RBC ... Algorithm #Diagnosis #Workup ... #Hematology #Microcytic
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell (RBC ... , Liver diseases ... , Liver diseases ... coagulopathy (DIC) #RBC ... #differential #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
2) External (RBC ... , Drugs, Liver Disease ... 3) Internal (RBC ... Defects: Sickle cell anemia ... Electrolytes: Wilson's disease
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Autoimmune Hemolytic Anemia ... DIAGNOSE AIHA • Anemia ... ↑ LDH • Anti-RBC ... diagnosis #management #treatment ... #rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Microangiopathic hemolytic anemia ... usually IgG) (e.g. lupus ... • Intrinsic RBC ... differential #diagnosis #hematology ... #anemia
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