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diagnosis hematology causes management disseminated hemolysis treatment agglutinin atlas autoimmune bloodsmear classification cold disease extravascular hodgkins honc hospitalization key laboratoryfindings
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... coagulation (DIC ... • Intrinsic RBC ... #Hemolytic #Intravascular ... #Causes #differential
Peripheral blood findings in microangiopathic hemolytic anemia. DIC is a clinical and laboratory diagnosis, not
Peripheral blood ... DIC is a clinical ... as disseminated intravascular ... coagulation and ... #Pathology #Smear
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Warm Antibody Autoimmune ... Hemolytic Anemia ... ↑ LDH • Anti-RBC ... type ± C3d • Blood ... smear: Differential
Therefore, studies obtained at the initial presentation in the emergency department should evaluate for fibrinolysis with
A complete blood ... as a peripheral smear ... microangiopathic hemolytic ... #Disseminated #Intravascular ... #Coagulation #Labs
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell ( ... spherocytosis, Hemolytic ... , Disseminated intravascular ... coagulopathy (DIC ... key #diagnosis #differential
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... MAHA: TTP, HUS, DIC ... Defects: Sickle cell anemia ... - Peripheral Blood ... Smear ↑ abnormal
Schistocytes - The arrows point to schistocytes which are fragmented red blood cells. Also called schizocytes,
fragmented red blood ... anemia in which ... include disseminated intravascular ... coagulation, hemolytic ... #Smear #Schistocytes
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Coagulation (DIC ... ABO incompatible blood ... protein C and S Pathophysiology ... organ damage Clinical ... • Peripheral smear
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
reflection of intravascular ... of Peripheral blood ... smear - Shows schistocytes ... from ischemia WBC ... count and differential
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Viral Infection Clinical ... smear - RBC agglutination ... younger pts) Differential ... sensitize red blood ... the RBCs causing intravascular
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