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causes coagulation pt management abnormal aptt bleeding blood bruising comparison disorders pathophysiology product prolonged ptt reactions thrombocytopenia afib algorithm anticoagulant
Anticoagulants Common Reversal Agents - Warfarin (Coumadin) → Vitamin K (Phytonadione), 4-factor PCC (Kcentra) - Heparin/LMWH
Reversal Agents - Warfarin ... PCC (Kcentra) - Heparin ... PCC (Kcentra) #anticoagulation ... #doac #noac #pharmacology ... #hematology #reversal
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Anticoagulants (Warfarin ... deficiency • Liver ... #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Diagnosis Algorithm ... Sequestration Disordered Platelet ... - Acquired • Anticoagulation ... Iatrogenic) • Liver ... #Causes #Hematology
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
clot #PT #PTT #diagnosis ... #models #hematology ... pathophysiology #anticoagulation ... anticoagulant #Warfarin ... Rivaroxaban #Edoxaban #heparin
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
Medications - Heparin ... , LMWH, warfarin ... ) • Advanced Liver ... table #comparison #diagnosis ... #hematology #deficiency
Prothrombin Time (PT) and Partial Thromboplastin Time (PTT) Prothrombin Time (PT) - Often Elevated in: • Vitamin
or antagonism (warfarin ... inhibitor • Liver ... elevated in: • Heparin ... Thromboplastin #laboratory #hematology ... #diagnosis
CHA2DS2VASc vs HAS-BLED scores for stroke risk and bleed risk on anticoagulation C Congestive Heart Failure 1 H Hypertension 1 A2 Age >75 2 D Diabetes Mellitus 1 S2 Stroke,
Abnormal renal/liver ... >2.3mg/dL) 1 Liver ... D Drugs Anti-platelet ... #AFib #Diagnosis ... #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Disorders - Differential ... Diagnosis and Workup ... : INR/PT, aPTT(liver ... bypass), LFT (liver ... #Workup #hematology
Platelet Disorders - Differential Diagnosis Framework Qualitative Defects: • Adhesion • Aggregation • Secretion Quantitative Defects: • Production:
Platelet Disorders ... - Differential ... Diagnosis Framework ... • Production: Liver ... #Diagnosis #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... Supratherapeutic warfarin ... • Reduced liver ... #differential # ... hematology #coagulation
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