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diagnosis differential hepatology management rheumatology aih anemia antibodies autoantibodies biliary causes chronic cirrhosis comparison dili diseases druginduced fatigue hemeonc hemophagocytic
Primary Biliary Cirrhosis - Diagnosis Algorithm Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort Signs: Jaundice, Xanthelasmata, Hepatomegaly Associated history:
quadrant discomfort Signs ... disease (e.g. dryness ... specific ANAs (e.g ... Liver biopsy findings ... #Algorithm #hepatology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Dermatomyositis Anti-LKM (liver ... syndrome Anti-Scl ... - Vasculitis, e.g ... - Vasculitis, e.g ... #diseases #diagnosis
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
Algorithmic Approach ... - Extrinsic: Autoimmune ... aciduria, Drugs (e.g ... Non-megaloblastic: Liver ... #hematology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
Immunosuppression (e.g ... the spleen or liver ... diseases (e.g., ... Malignancies (eg ... NonHodgkins #comparison #oncology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Algorithm DILI ... of information (e.g ... vascular disorder (e.g ... steatosis • Autoimmune ... #Algorithm #hepatology
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Algorithm Endocrine ... Renal Failure • Liver ... Neoplastic / Hematologic ... Hepatitis • HIV Autoimmune ... • Drug Abuse (e.g
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
Autoimmune Hepatitis ... inflammation (eg ... been reported (eg ... of Hepatitis (eg ... Histology Findings (eg
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
▪ Infections (e.g ... - Elevated liver ... pro-inflammatory cytokines (e.g ... Immunosuppression (e.g ... anti-IFN-γ antibodies (e.g
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
- Differential Diagnosis ... Aldolase levels • EMG ... papules and Gottron sign ... ) • Shawl sign ... (also seen in association
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