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diagnosis hematology management differential leukemia chronic hemeonc hemophagocytic hlh hodgkins lymphocytic lymphohistiocytosis lymphoma mds myelodysplastic syndrome workup algorithm anemia cell
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... ) (e.g. lupus, CLL ... Hypersplenism, Wilson's ... disease, Copper ... differential #diagnosis #hematology
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
Causes of false- ... amyloidosis Other causes ... diseases, CML, ... MGUS #diagnosis #hematology ... #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... -> AML: Blast crises ... ) CLL Symptoms: ... #Leukemia #Hematology ... #Oncology #Diagnosis
Causes of Localized Lymphadenopathy - Differential Diagnosis Algorithm Cervical: - Anterior • Infection
Causes of Localized ... • Kikuchi Disease ... of infection in upper ... Diagnosis #Algorithm #Causes ... #Hematology #Oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
incompetent • CLL ... cells can indicate disease ... microglobulin Treatment ... diagnosis #workup #oncology ... #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
old, ~10,000 new cases ... Allogeneic stem cell ... only curative treatment ... Diagnosis #Management #treatment ... #hematology #oncology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
infection, Autoimmune diseases ... Lymph nodes in upper ... - Autoimmune diseases ... NonHodgkins #comparison #oncology ... #differential #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Lymphocytic Leukemia (CLL ... chemotherapy for low-risk disease ... uw_IMresidency #CLL ... Lymphocytic #Leukemia #oncology ... #hematology #hemeonc
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... Myeloproliferative Disease ... • Copper deficiency ... Syndromes #diagnosis #hematology ... #oncology
Hemophagocytic Lymphohistiocytosis (HLH) Treatment Primary HLH: - HLH-94 Protocol • Dexamethasone
Lymphohistiocytosis (HLH) Treatment ... or autoimmune disease ... , treatment of underlying ... for refractory disease ... #management #hematology
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