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diagnosis management antibodies antinuclear differential druginduced erythematosus neurology antineutrophil classification clues cns comparison cryoglobulinemia cryoglobulins dil diseases inflammatory patterns sjogrens
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antibody) and ANCA ... ) • Systemic lupus ... in drug-induced SLE ... • Sjögren syndrome ... antibodies #diagnosis #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... Demyelinating Syndrome ... autoantibodies that will cause ... Erythematosus #SLE ... CNS #neurology #rheumatology
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear Visual or auditory symptoms in conjunction
BEE Syndromes - ... treatment can prevent ... Inflammatory causes ... • Systemic lupus ... spectrum disorder • ANCA-associated
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Workup: - ANA ... Discontinuation of causal ... Workup: - ANA ... life-threatening • Treatment ... #table #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antibody refers ... • +ANA can be seen ... ), Sjogren's Syndrome ... Arthritis, Sjögren Syndrome ... #patterns #rheumatology
Top 10 situations when to think about lupus 1) Inflammatory joint pain (especially in the wrists and
especially in the wrists ... pericarditis (search ANA ... pleurisy (search ANA ... person (search ANA ... infection has been
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... DDX: • ANCA (Antineutrophil ... cytoplasmic antibody ... (e.g. systemic lupus ... classification #rheumatology
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
is rare in DIL, SCLE-DIL ... Workup: - ANA ... Discontinuation of causal ... #DIL #rheumatology ... #diagnosis #treatment
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
6th Decades (can be ... overlaps with RA, SLE ... phenomenon (16%) MSK ... Adenocarcinoma Treatment ... #Rheumatology #
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
including systemic lupus ... erythematosus (SLE ... , ANCA-associated ... Hypoalbuminemia Treatment ... diagnosis #management #rheumatology
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