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diagnosis management erythematosus systemic hematology acute ana antinuclear arthritis autoantibodies classification differential disease hemeonc hemophagocytic hiv hlh laboratory lymphohistiocytosis macrophage
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... Initial screening test ... severe disease Treatment ... #Systemic #Lupus ... Summary #diagnosis #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... Syndrome (MAS) ... erythematosus [SLE ... Liver function tests ... Treatment: • Corticosteroids
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... and Systemic lupus ... clinically suspected, tests ... overlap syndromes ... erythematosus #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Non-autoimmune rheumatologic ... 1, SCL-70, RNP antibodies ... anticardiolipin antibodies ... Chronic B-cell activation
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... joint • Systemic lupus ... erythematosus (SLE ... double-stranded DNA antibodies ... diagnosis #testing #Rheumatology
Acute Retroviral Syndrome Acute Retroviral Syndrome is the symptomatic presentation of acute human immunodeficiency virus infection •
• Presents as ... • New onset SLE ... after exposure • Antibodies ... HIV-1 or HIV-2 antibodies ... ) Treatment:
Statin Induced Muscle Toxicity - Summary Clinical Presentation: • Elevations of serum creatine kinase with proximal myalgia
any time during treatment ... Guillain-Barré syndrome ... GBS), systemic lupus ... erythematosus (SLE ... myopathy (IMNM) → Antibodies
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
systemic lupus ... retinopathy Lab Tests ... C-ANCA) pattern: antibodies ... vasculitis, and SLE ... differential #diagnosis #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
hyperinflammatory syndrome ... (often termed MAS-HLH ... Syndrome) 3. ... inhibitors, anti-IFN-γ antibodies ... Diagnosis #Management #Hematology
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
: • SLE • RA - ... Diagnosis: • Clinical tests ... Anti-Matrilin-1 Ab ○ Antibodies ... affected tissue Treatment ... Polychondritis #rheumatology
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