19 results
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
>>> MPA > eGPA ... • MPO-ANCA (P-ANCA ... ): eGPA, MPA >>> ... #differential # ... #rheumatology
ANCA Associated Vasculitis (AAV) - Auto-antibodies and Differential Diagnosis

MPA → usually p-ANCA
GPA → usually c-ANCA
EGPA →
Diagnosis MPA ... usually p-ANCA GPA ... usually c-ANCA EGPA ... 50% P-ANCA (MPO ... #AAV #Differential
ANCA Vasculitis - GPA, MPA, Eosinophilic GPA

doi:10.1038/s41572-020-0204-y

#ANCA #Vasculitis #GPA #MPA #Eosinophilic #rheumatology #diagnosis #comparison #table
- GPA, MPA, Eosinophilic ... GPA doi:10.1038 ... #GPA #MPA #Eosinophilic ... #rheumatology # ... diagnosis #comparison
ANCA-Associated Vasculitis
A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
polyangiitis (GPA ... polyangiitis (EGPA ... associated with MPO ... #PR3 #Diagnosis ... #Rheumatology
2021 ACR/VF Guidelines for Management of Granulomatosis with Polyangiitis (GPA) and Microscopic Polyangiitis (MPA)

#Granulomatosis #Polyangiitis #GPA
Polyangiitis (GPA ... Polyangiitis (MPA ... #Polyangiitis #GPA ... #Polyangiitis #MPA ... #rheumatology #
Frequency of ANCA Positivity in Different Conditions
ANCA-Associated Vasculitis
 • GPA - PR3-ANCA 75%, MPO-ANCA 20%, 5%
GPA - PR3-ANCA ... 75%, MPO-ANCA 20% ... ANCA negative • EGPA ... #PR3 #diagnosis ... #rheumatology
Vasculitis Management - ACR/VF 2021 Guidelines for Treatment & Management
 • Giant Cell Arteritis (GCA)
 •
Vasculitis Management ... Polyangiitis (GPA ... Polyangiitis (MPA ... Polyangiitis (EGPA ... Guidelines #algorithm #rheumatology
Granulomatosis with Polyangiitis (GPA) and Microscopic Polyangiitis (MPA) - ANCA Vasculitis Management Algorithm - ACR/VF 2021
Polyangiitis (GPA ... Polyangiitis (MPA ... #Polyangiitis #GPA ... #Polyangiitis #MPA ... Guidelines #algorithm #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Granulomas - MPO ... > PR3 60% • GPA ... • ANCA (Dx: GPA ... differential #diagnosis ... #rheumatology #
ANCA-Associated Vasculitis
There are many definitions, but most come down to the presence of granulomas (pathologically or
ANCA-Associated Vasculitis ... polyangiitis (GPA ... #differential # ... diagnosis #algorithm ... #rheumatology