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diagnosis differential algorithm classification granulomatosis mpo polyangiitis pulmonary treatment acr2021 associated canca cryoglobulinemia cryoglobulins cutaneous dermatologic glomerulonephritis guidelines hematology hemoptysis
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... GPA >>> MPA > eGPA ... • MPO-ANCA (P-ANCA ... ): eGPA, MPA >>> ... GPA Stanford Internal
ANCA-Associated Vasculitis A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
polyangiitis (GPA ... polyangiitis (MPA ... polyangiitis (EGPA ... vasculitis - MPO ... #Rheumatology
Frequency of ANCA Positivity in Different Conditions ANCA-Associated Vasculitis • GPA - PR3-ANCA 75%, MPO-ANCA 20%, 5%
GPA - PR3-ANCA 75% ... • MPA - PR3-ANCA ... • EGPA - PR3- ... - PR3-ANCA 10%, ... #rheumatology
Granulomatosis with Polyangiitis (GPA) and Microscopic Polyangiitis (MPA) - ANCA Vasculitis Management Algorithm - ACR/VF 2021
Polyangiitis (GPA ... ) - ANCA Vasculitis ... #Polyangiitis #GPA ... #Polyangiitis #MPA ... #ANCA #Vasculitis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
capillaritis • EGPA ... > PR3 60% • GPA ... tract, and often causes ... Vasculitis: + MPO-ANCA ... (Dx: GPA, EGPA,
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
): GPA (granulomatous ... polyangiitis), MPA ... subglottic stenosis) in GPA ... Goodpasture's cause ... differential #diagnosis #management
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- GPA - EGPA ... - MPA • CTD ... Differential #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Vasculitis Involving the Skin - Differential Diagnosis Framework Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis Secondary: CTD: SLE, RA
• ANCA Associated ... polyangiitis - EGPA ... - GPA Cutaneous ... #skin #dermatology ... #rheumatology #
Hemoptysis - Differential Diagnosis Framework Massive Hemoptysis: >150-300 mL in 24h Airway disease: • Bronchitis, Bronchiectasis, Malignancy
Kaposi's sarcoma • Rheumatologic ... / Autoimmune: ANCA-Assoc ... vasculitis (GPA ... > EGPA, MPA), Cryoglobulinemia ... Diagnosis #pulmonary #causes
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Polyangiitis (GPA ... polyangiitis (GPA ... GPA causes disease ... polyangiitis • EGPA ... #Polyangiitis #GPA
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