15 results
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Initial screening test ... block • Sjogren syndrome ... polymyositis overlap syndrome ... #SLE #Summary #diagnosis ... #rheumatology #
Joint Disorders - Differential Diagnosis Algorithm
Monoarthritis
 • Septic
 • Crystalline
     - Gout
- Differential Diagnosis ... arthritis - (Reiter’s syndrome ... inflammation is secondary ... with Systemic Lupus ... Joint #Disorders #msk
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... Cerebrovascular Disease ... permeability Diagnosis ... APS), Secondary ... CNS #neurology #rheumatology
Causes of Secondary Hypertension - Differential Diagnosis and Screening Testing
Common causes: 
 • Renal parenchymal disease
Causes of Secondary ... - Differential Diagnosis ... • Cushing’s syndrome ... Mineralocorticoid excess syndromes ... Causes #Screening #Workup
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation Syndrome ... Classified among the secondary ... Periodic fever syndromes ... hypersensitivity syndromes ... Macrophage #Activation #Syndrome
Primary and Secondary Causes of Hypertension - Differential Diagnosis Algorithm
Primary (Essential) (95%) - Onset between age
- Differential Diagnosis ... taken at home, work ... excess (Cushing syndrome ... #HTN #Cardiology ... #Differential #Diagnosis
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Association with disease ... clinically suspected, tests ... SLE-SSc-AlM overlap syndromes ... erythematosus #diagnosis ... #rheumatology #
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Hyperviscosity Syndrome ... Cryoglobulinemia Syndrome ... cryoglobulinemia syndrome ... Cryoglobulinemia Syndrome ... 20% Sjögren's syndrome
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
AIHA Primary Secondary ... lymphoproliferative disorder Secondary ... Cold Agglutinin Syndrome ... Test: Donath-Landsteiner ... test #cold #
Polycythemia - Differential Diagnosis Algorithm
Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
you’ll do a good workup ... can drive this disease ... As with many disease ... Best to have an ... #Algorithm #workup