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Familial Hypertension Syndromes

-  Dr. James Luther (@DrJMLuther)

#Inheritable #Familial #Hypertension #Syndromes #Comparison #Table #Diagnosis #Management
Familial Hypertension ... Syndromes - ... #Hypertension # ... #Table #Diagnosis ... #Management
Pocket Comparison Guide to Heritable Hypertension Syndromes (Secondary Hypertension)

Bartter, Gitelman, Liddle, Primary Aldosteronism, 
GRA (Glucocorticoid Remediable
Syndromes (Secondary ... #Inheritable #Familial ... Syndromes #Comparison ... #Table #Diagnosis ... #Management #Secondary
Hypomagnesemia - Differential Diagnosis
Renal Causes of Hypomagnesemia - Familial:
Bartter syndrome and Gitelman syndrome, Isolated recessive hypomagnesemia,
Hypomagnesemia - Familial ... : Bartter syndrome ... and Gitelman syndrome ... hypomagnesemia, Familial ... diagnosis #causes #nephrology
Secondary Causes of Hypertension - Differential Diagnosis Algorithm
Hypertension - BP > 140/90 (>130/80 for DM)
Hypertensive urgency
multi-drug resistance) Renal ... • Nephritic syndrome ... Excess: • Conn's syndrome ... Licorice • Liddle's syndrome ... HTN #Secondary #Nephrology
Hypomagnesemia - Etiologies by Mechanism

Decreased GI Uptake 
 - Poor dietary intake (particularly common in alcoholics)
diarrhea / IBD Renal ... - Alcohol - Familial ... renal Mg wasting ... syndromes ... Low #Magnesium #Table
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
Agents Regulating Renal ... alkalosis • Familial ... irrigation • Management ... Excretion #Diuresis #Nephrology ... #Medications #Table
Causes of Secondary Hypertension - Workup and Differential Diagnosis
Approach (when evaluation should be done):
1. Severe or
with previously stable ... heart failure, neurologic ... Renal parenchymal ... White-coat syndrome ... Neurologic disorders
Renal Tubular Acidosis (RTA) Diagnosis and Management
 • Distal (type 1) RTA
 • Proximal (type 2)
Renal Tubular Acidosis ... Diagnosis and Management ... 4) RTA #rta #Renal ... Acidosis #Diagnosis #Management ... #nephrology #table
ACEI Antihypertensive Dose Comparison. Consider divided (BID) regimen for better pre-dose (trough) BP control for the
potassium, and renal ... #Pharmacology #Hypertension ... #Management #PrimaryCare ... #Comparison #Table
Workup for Hyperphosphatemia - Differential Diagnosis Framework
Rule out spurious hyperphosphatemia: paraproteinemia, hyperlipidemia, hemolysis, hyperbilirubinemia, liposomal amphotericin
Rhabdomyolysis, Tumor lysis syndrome ... CKD Increased Renal ... FGFR inhibitors, Familial ... Workup #phosphate #nephrology