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differential management hematology symptoms dermatology systemic algorithm lupus sle arthritis treatment causes pathophysiology syndrome msk summary antinuclear classification clinical comparison
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
Associated Rheumatic Diseases ... Systemic lupus erythematosus ... connective tissue disease ... #patterns #rheumatology ... #diagnosis #differential
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... Antinuclear (ANA ... Hydroxychloroquine *Short ... #SLE #Summary #diagnosis ... #rheumatology #
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... • Immunologic Workup ... : - ANA > ... Evolution: Chronic disease ... #Summary #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... Auto-Antibodies: - ANA ... sclerosis, Still's disease ... #signs #symptoms ... #differential #rheumatology
Rheumatoid Arthritis Summary MCP and PIP Involvement, Spares DIP, Carpal Tunnel, Sicca Syndrome, Epi/Scleritis, Heart Disease, Rheumatoid
PIP Involvement, Spares ... Scleritis, Heart Disease ... Arthritis #RA #diagnosis ... #rheumatology # ... signs #symptoms
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
findings (ANA, ... Differential Diagnosis ... Non-autoimmune rheumatologic ... • Malar rash - spares ... #Diagnosis #Rheumatology
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
Multi-system autoimmune disease ... distal to elbows/wrists ... Scleroderma #SSc #rheumatology ... #diagnosis #signs ... symptoms #testing #workup
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Systemic lupus erythematosus ... Systemic lupus erythematosus ... Systemic lupus erythematosus ... #patterns #rheumatology ... #diagnosis #differential
Classification of Vasculitis Vasculitis of large vessels - Arteritis temporalis (giant-cell arteritis) - Takayasu
drugs, malignomas, and ... systemic lupus erythematosus ... Vasculitis #Vessels #Diagnosis ... #Rheumatology # ... Diagnosis
Erythematous Rashes - THE ALGORITHMIC APPROACH Characterized by diffuse redness of the skin due to capillary congestion, erythematous
the Nikolsky sign ... are present, the diagnosis ... the Nikolsky sign ... includes Kawasaki disease ... fever or Nikolsky sign
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