15 results
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Tests - Differential ... or AST > ALP): ... AIH, Wilsons, Pregnancy ... - AFLP, HELLP
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs R-value ... disease • If ALP ... #chemistry #diagnosis ... #differential # ... Hepatology #transaminitis
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
) Elevation - Differential ... ALP: - Enzymes ... - Increased ALP ... #Elevation #Differential ... #hepatology
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
ALP - Biliary ... ≥ 2x ULN R Value ... ) / (ALP / ULN ALP ... Transaminitis #diagnosis ... #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
- Differential ... Diagnosis Algorithm ... melanoma, myeloma • Pregnancy ... GGT/5-NT: ↑ - ALP ... #hepatology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
of Pregnancy (AFLP ... : • Defect in fetal ... infiltration) Differential ... iMedEducation #AFLP ... Pregnancy #hepatology
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
of Pregnancy (AFLP ... #hepatology #obstetrics ... hepatitis #comparison #differential ... #diagnosis #icp ... #HELLP #AFLP
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury
Hepatocellular Liver Injury
 • AST/ALT elevation
elevation > Alk ... • R value = (ALT ... Transaminitis #diagnosis ... #differential # ... hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... - Differential ... • Wilson's • Pregnancy ... - AFLP, HELLP ... Others #LFTs #Hepatology
Primary Biliary Cirrhosis - Diagnosis Algorithm
Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort
Signs: Jaundice, Xanthelasmata, Hepatomegaly
Associated history:
pruritus after pregnancy ... Diagnose PBC if ... Elevated ALP 2. ... Liver biopsy findings ... #Algorithm #hepatology