18 results
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
and Acute Fatty Liver ... of Pregnancy (AFLP ... Hemolysis, Elevated Liver ... TTPHUS #HELLP #AFLP ... #obstetrics #hematology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
of Pregnancy (AFLP ... : • Defect in fetal ... Maternal Support - Critical ... iMedEducation #AFLP ... Pregnancy #hepatology
Thrombocytopenia and Pregnancy
Three syndromes in the critically ill pregnant woman who presents with coagulation defects.
1) HELLP
Hemolysis, Elevated Liver ... exchange 2) Fatty liver ... coagulation defects and liver ... TTPHUS #HELLP #AFLP ... Obstetrics #OBGyn #Hematology
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
weeks • Typical clinical ... post-partum • Typical clinical ... of Pregnancy (AFLP ... #hepatology #obstetrics ... diagnosis #icp #HELLP #AFLP
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... (ALT or AST > ALP ... AIH, Wilsons, Pregnancy ... - AFLP, HELLP ... Algorithm #diagnosis #hepatology
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
Liver Function Test ... specific for the liver ... ≥ 2x ULN R Value ... SinaiBmoreIMRes #Liver ... Transaminitis #diagnosis #hepatology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
- Increased ALP ... disturbance (obstructed liver ... Highest • Bone • Liver ... - Drugs - Pregnancy ... Diagnosis #Algorithm #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... • Wilson's • Pregnancy ... - AFLP, HELLP ... Others #LFTs #Hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Liver Chemistries ... Interpretation of LFTs R-value ... Identify Acute Liver ... - Specific to liver ... #differential #Hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
melanoma, myeloma • Pregnancy ... • AST/ALT > ALP ... disease - If ALP ... hemolysis) • ALP ... diagnosis #algorithm #hepatology