16 results
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Megakaryopoiesis • Aplastic Anemia ... Toxic Damage (e.g ... Displacement (e.g ... Foreign Surface (e.g ... #Hematology
Causes of Fatigue - Differential Diagnosis Algorithm
Endocrine
 • Hypo/Hyperthyroidism
 • Diabetes
 • Pituitary Insufficiency
 • Adrenal
Causes of Fatigue ... Hematologic • Anemia ... Tuberculosis • Epstein-Barr ... Hepatitis • HIV ... • Drug Abuse (e.g
Guillain-Barre Syndrome - Summary

Acute AIDP that presents with rapidly progressive flaccid weakness

Epidemiology:
 • 1-2 cases/100,000 per
Epidemiology: • 1-2 cases ... Pathophysiology ... Campylobacter jejuni - HIV ... Electrodiagnostic studies - EMG ... Syndrome #diagnosis #management
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Risks factor for HIV ... peripheral blood smear, HIV ... function test, ANA (e.g ... changes), high MCV anemia ... #Workup #hematology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
and petechiae Causes ... - HCV - HIV ... CMV) • Epstein-Barr ... #oncology #hematology ... #diagnosis #management
Guillain-Barré Syndrome (GBS)
Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness
Epidemiology:
 • Incidence: 1
Incidence: 1 to 2 cases ... immunodeficiency virus (HIV ... Electrodiagnostic studies (Ex EMG ... the underlying pathophysiology ... Syndrome #diagnosis #management
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Disease, PRES Pathophysiology ... autoantibodies that will cause ... Lumbar Puncture, EEG ... CNS #neurology #rheumatology ... cerebritis #diagnosis #management
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... high WBC count cause ... unless worrisome EKG ... TLS #diagnosis #management ... #hematology
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
autoimmune hemolytic anemia ... DDX - Other causes ... infections (Epstein-Barr ... syndrome, HIV) ... #diagnosis #management
Lung Abscess - Diagnosis and Management Summary

Lung Abscess Etiology:
 • Necrosis of lung parenchyma by a
• Most common cause ... Lung Abscess Pathophysiology ... Leukocytosis, anemia ... • Vasculitis (e.g ... #differential #causes