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diagnosis differential hematology classification algorithm autoimmune conditions cryofibrinogenemia cryoglobulinemia cryoglobulins embolism endocarditis extrarticular infectiousdiseases joint leukostasis lysis management myopathy myositis
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Toxic Damage (e.g ... Displacement (e.g ... Non-lmmune: • HELLP Syndrome ... HUS • DIC • Vasculitis ... Foreign Surface (e.g
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Hematological: - HIT ... • Nephrotic Syndrome ... in young patients ... 19 - PNH - Vasculitis ... #pathophysiology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... HBV infection, HIV ... tissue disorder (e.g ... classification #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... - Coronary arteries ... Thrombosis and arterial ... purpura: strong sign ... differential #diagnosis #rheumatology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... high WBC count cause ... WBC >100k, + lab signs ... : • Pathophysiology ... unless worrisome EKG
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
• Acute stroke syndromes ... Lack of UMN/LMN signs ... parainfluenza, Coxsackie, HIV ... , CMV, EBV - Bacterial ... electromyographic (EMG
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Lyme disease, Vasculitis ... (e.g., PAN) ... Heberden's nodes (DIP ... Bouchard's nodes (PIP ... differential #diagnosis #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
purpura: Strong sign ... of shoulder and hip ... • Coronary arteries ... tract, and often causes ... Differential #Diagnosis #Rheumatology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
cryoglobulin (CG ... malignancies, vasculitis ... cryoglobulins • Negative causes ... • TTP, HUS and HIT ... Antiphospholipid syndrome
Endocarditis - Overview and Differential Diagnosis Framework Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV
Libman Sacks) • Atrial ... valvular disease • Vasculitis ... Cholesterol emboli syndrome ... ↑ ESR, CRP • EKG ... Differential #Diagnosis #cardiology
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