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diagnosis differential management rheumatology algorithm chronic classification crisis cryoglobulinemia cryoglobulins erythematosus extravascular fatigue fever fuo gca giantcell gravis hemolysis hemolytic
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Megakaryopoiesis • Aplastic Anemia ... Toxic Damage (e.g ... Displacement (e.g ... Foreign Surface (e.g ... #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
(usually IgG) (e.g ... (usually IgM) (e.g ... deficiencies (e.g ... Membrane defects (e.g ... differential #diagnosis #hematology
Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis • Infection: Extrapulmonary tuberculosis, Abscess, Endocarditis,
Infected thrombosis, (e.g ... Lemierre's syndrome ... Malignancy: - Hematologic ... Inflammatory Diseases (e.g ... . autoimmune): Lupus
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Neoplastic / Hematologic ... • Anemia • ... • Rheumatoid Arthritis ... • Drug Abuse (e.g ... Chronic Fatigue Syndrome
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
malignancies • Anemia ... inflammatory disorders (e.g ... . autoimmune, TB ... Myelodysplastic syndrome ... #hematology #secondary
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... infection • Autoimmune ... arthralgia, and arthritis ... tissue disorder (e.g
Causes of Neutropenia - Differential Diagnosis Neonate: - Infection - by far the most common cause -
Constitutional disorders, eg ... neutropenia, Kostmann syndrome ... Chediak-Higashi syndrome ... Megaloblastic anemia-rare ... #hematology
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
Myasthenia Gravis is an autoimmune ... Hodgkin lymphoma - Autoimmune ... , rheumatoid arthritis ... Serologic and EMG ... diagnosis #management #neurology
Stiff Person Syndrome (SPS) - Diagnosis and Management Summary Epidemiology: • Prevalence: 1-2 cases per million -
and pernicious anemia ... the result of an autoimmune ... unit activity on EMG ... of diazepam • EMG ... TPO, TTG, etc EMG
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
disease • Non-autoimmune ... • Malignancy (e.g ... Endocrine disorders (e.g ... deficiencies • Autoimmune ... lymphopenia, low PLT • Anemia
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