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diagnosis differential management hematology neurology signs symptoms erythematosus fingers hands pediatrics phenomenon physicalexam raynauds sle systemic water activation anemia bleeding
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
(usually IgG) (e.g ... . lupus, CLL, lymphoma ... (usually IgM) (e.g ... deficiencies (e.g ... Membrane defects (e.g
Raynaud's Syndrome - Washing off under hot water. Raynaud phenomenon is an exaggerated vasoconstrictive response of the
Raynaud's Syndrome ... and arterioles (e.g ... #disease #phenomenon ... #clinical #video ... fingers #hands #rheumatology
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 CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE) Clinical ... Demyelinating Syndrome ... Cerebrovascular Disease ... autoantibodies that will cause ... Lumbar Puncture, EEG
Raynaud's Syndrome - Washing off under hot water wath. Raynaud phenomenon is an exaggerated vasoconstrictive response of
Raynaud's Syndrome ... and arterioles (e.g ... #disease #phenomenon ... #clinical #video ... fingers #hands #rheumatology
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 Neuromyelitis Optica (NMO) - Clinical Manifestations • Optic neuritis: Reduced visual acuity, ranging from mild to
Optica (NMO) - Clinical ... involvement: Intractable nausea ... (e.g. oculomotor ... ; e.g. narcolepsy ... disorders (Systemic lupus
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
• Systemic lupus ... (eg, systemic juvenile ... SJIA], systemic lupus ... • Infection (eg ... #Rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... Non-autoimmune rheumatologic ... • Malignancy (e.g ... Endocrine disorders (e.g ... Clinical Features
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
SLE (systemic lupus ... infiltration (e.g ... Rare disorders, e.g ... - Vasculitis, e.g ... #peds #pediatrics
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
: • Clinical triad ... • Autoimmune diseases ... tissue disorder (e.g ... . systemic lupus ... classification #rheumatology
Causes of Secondary Hypertension - Workup and Differential Diagnosis Approach (when evaluation should be done): 1. Severe or
risk factors (eg ... hypertension (eg ... 109 mm Hg) with clinical ... hypertension (eg ... Renal parenchymal disease
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