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Pharmacology of diuretics Acetazolamide, Loop diuretics, Thiazide‐like diuretics, MRA, Amiloride Site of Action, Maximum Dose, Half-Life, Onset, Bioavailability,
of diuretics Acetazolamide ... , Loop diuretics ... HalfLife #Dosing #Loop
Mechanism of Action of Diuretics Amiloride, Triamterene, Spironolactone Loop Diuretics Thiazides Acetazolamide #Diuretics #Mechanism #Action #pharmacology #pathophysiology #nephrology
Spironolactone Loop ... Diuretics Thiazides Acetazolamide
Overview of effects of diuretics and hormones involved in fluid homeostasis. #diruetic #diuretics #aldosterone #ADH #ANP #BNP #thiazide
hydrocholorothyazide #loop ... anhydrase #inhibitor #acetazolamide
Nephron Pathophysiology - Diuretic Sites of Action Diuretics 1) Acetazolamide/canagliflozin 2) Osmotic agents (mannitol, urearetics) 3) Loop agents (eg, furosemide) 4)
Diuretics 1) Acetazolamide ... urearetics) 3) Loop
Hormones Acting on the Nephron - Diuretics and Their Site of Action 1) Acetazolamide 2) Osmotic
of Action 1) Acetazolamide ... mannitol) 3) Loop
Diuretics sites of action on the nephron 1) Acetazolamide (carbonic anhydrase inhibitor) 2) Osmotic diuretics (e.g. mannitol) 3) Loop
the nephron 1) Acetazolamide ... . mannitol) 3) Loop
Thiazide diuretics Carbonic anhydrase inhibitors (e.g., acetazolamide) Nat-Cl symport Na and HCO;- reabsorption Aldosterone antagonists (e.g., spironolactone) Nat channel (indirect effect) Loop diuretics (e.g., furosemide) Amiloride, #triamterene Nat-K+-2CF symport Na channel (direct effect) #NaCI reabsorption
inhibitors (e.g., acetazolamide ... indirect effect) Loop
Summary of Diuretic Agents Subclass, Drug, Mechanism of Action, Effects, Clinical Applications, Pharmacokinetics, Toxicities, Interaction CARBONIC ANHYDRASE
INHIBITORS • Acetazolamide ... empagliflozin LOOP
Diuretics - Pharmacology Thiazides diuretics: • Inhibit Na+ Cl- cotransporter in distal tubule • Chlorothiazide, Chlorthalidone, Indapamide,
Metolazone Loop ... proximal tubule • Acetazolamide ... nephrology #conversion #loop
Drugs associated with hypokalemia and hypomagnesemia Hypokalemia - Shift from extracellular fluid to intracellular fluid compartment -
Diuretics - Acetazolamide ... Furosemide and other loop
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