8 results
Inherited Qualitative Platelet Defects
Bernard-Soulier Syndrome
 • Defect of adhesion due to a lack of GP Ib/IX/V
Inherited Qualitative ... Bernard-Soulier Syndrome ... MYH9-Related Disorder ... Defects #comparison #table ... #differential #
Schematic representation of the major sources of ammonia production and its excretory pathway (GI = gastrointestinal,
of ammonia: - Inherited ... Urea Cycle Disorders ... rare): - Reye syndrome ... deficiency #Ammonia #Pathophysiology ... Hyperammonemia #Differential
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework

VENOUS THROMBOSIS

 • Acquired Risk Factors:
	- >48 hours
thromboembolism • Inherited ... • Nephrotic Syndrome ... considered in all ... Venous #Arterial #pathophysiology ... #hematology #differential
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... Incidence: common in APL ... ATRA treatment Pathophysiology ... initiation • Differential ... #oncology
Causes of ST Segment Elevation - Differential Diagnosis Framework

STEMI:
 • Upsloping convex STE: "Pardee's sign" +
Segment Elevation - Differential ... Electrolyte Disorders ... through V5 with inverted ... Segment #Elevation #differential ... diagnosis #cardiology #ecg
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... Neutropenia • Platelet Disorders ... blood count with differential ... #diagnosis #hematology ... #oncology
Helpful Clinical Features in Evaluating Bleeding Disorders
Age of onset
 • Neonate - in 20% of haemophilias,
relatives (if all ... acquired rather then inherited ... Drug history, e.g ... Marfan syndrome, ... pediatrics #diagnosis #hematology
Hemophagocytic Lymphohistiocytosis (HLH)

High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
• In all patients ... with the HLH syndrome ... Pathophysiology ... malignancy, autoimmune disorder ... Diagnosis #Management #Hematology