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hyperkalemia diagnosis nephrology causes high management pathophysiology ada algorithm arb binder ckd diabetes druginduced egfr impaired insulin kbinder kdigo medications
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
Angiotensin-converting enzyme (ACE ... Increased EC shift of K ... #hyperkalemia #differential ... pathophysiology #pharmacology ... #potassium #medications
Drugs that Impair Renal Potassium Excretion Decreased ENaC channel function: Amiloride, Triamterene, Pentamidine Decreased Aldosterone Synthesis: Heparin,
that Impair Renal Potassium ... Aldosterone Release: ACE ... Decreased Na, K-ATPase ... Pathophysiology #Pharmacology ... #Impaired #Potassium
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Hyperkalemia - Differential ... • NSAIDs • ACE ... • Recent IV potassium ... Beta blockers • Antibiotics ... #hyperkalemia #differential
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Hyperkalemia - Differential ... • NSAIDs • ACE ... • Recent IV potassium ... Beta blockers • Antibiotics ... #hyperkalemia #differential
Emergent Hyperkalemia Treatment Algorithm ECG changes, weakness, K+ >6.5 Or renal insufficiency with K >5.5 with cellular
Emergent Hyperkalemia Treatment ... as a standalone treatment ... Remove potassium ... offending agent (ACE-I ... #Hyperkalemia #Treatment
Veltassa (Patiromer) MECHANISM: Potassium Binder INDICATION: Treatment of Hyperkalemia FORMULATION: Powder for oral suspension DOSING: 8.4
) MECHANISM: Potassium ... INDICATION: Treatment ... needed, based on K ... ACE inhibitors, ... #Hyperkalemia #Pharmacology
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
, ACEi/ARBs, NSAIDs ... , β-blockers, Antibiotics ... Ca-gluconate or 1g CaCl ... Redistribution Treatments ... #potassium #nephrology
Management of Diabetes Mellitus in Patients With CKD 1. Monitor for changes in BP, serum creatinine, &
creatinine, & serum K+ ... Continue ACEi or ... initiation of treatment ... Statements: All ... evidence-based pharmacologic
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