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diagnosis hyperkalemia nephrology algorithm management causes high pathophysiology binder criticalcare crystalloids druginduced foamed impaired kbinder medications patiromer physiology renal urine
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
of Drug-Induced Hyperkalemia ... Increased EC shift of K ... #differential # ... pathophysiology #pharmacology ... #potassium #medications
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine Urine K+
patients with hypokalemia ... the basis of the potassium-to-creatinine ... • Cell shift: Hypokalemic ... #urine #potassium ... #differential #
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Hyperkalemia - Differential ... • NSAIDs • ACE ... • Recent IV potassium ... Beta blockers • Antibiotics ... #differential #
Drugs that Impair Renal Potassium Excretion Decreased ENaC channel function: Amiloride, Triamterene, Pentamidine Decreased Aldosterone Synthesis: Heparin,
that Impair Renal Potassium ... Aldosterone Release: ACE ... Decreased Na, K-ATPase ... happypillsrx/ #Hyperkalemia ... Pathophysiology #Pharmacology
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Hyperkalemia - Differential ... • NSAIDs • ACE ... • Recent IV potassium ... Beta blockers • Antibiotics ... #differential #
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
NSAIDs, β-blockers, Antibiotics ... Stabilization Treatments ... Ca-gluconate or 1g CaCl ... Redistribution Treatments ... #potassium #nephrology
Veltassa (Patiromer) MECHANISM: Potassium Binder INDICATION: Treatment of Hyperkalemia FORMULATION: Powder for oral suspension DOSING: 8.4
) MECHANISM: Potassium ... INDICATION: Treatment ... needed, based on K ... ACE inhibitors, ... #Pharmacology
Emergent Hyperkalemia Treatment Algorithm ECG changes, weakness, K+ >6.5 Or renal insufficiency with K >5.5 with cellular
Emergent Hyperkalemia ... Treatment Algorithm ... Remove potassium ... offending agent (ACE-I ... not quickly) #Hyperkalemia
The crusade against “Ab”Normal Saline continues. This is a non-physiologic fluid that can harm our
is dominated by K+ ... as a too much K+ ... the ECF causes Hyperkalemia ... management #diagnosis #treatment ... #pharmacology #
Pragmatic diagnostic algorithm for hypokalemia. ***Typical presentations: • Vomiting: urine Na/Cl > 1.6, low urine
algorithm for hypokalemia ... Tubulopathy: urine K/ ... genetic testing *If hypokalemia ... correcting serum potassium ... #diagnosis #differential
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