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diagnosis hematology management oncology anemia causes disease hemolytic agglutinin algorithm apml behcet cd4 differentiation erythematosus extravascular hemolysis intravascular lupus lymphocytopenia
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
) - HELLP syndrome ... e.g. lupus, CLL, lymphoma ... , idiopathic) ... (e.g. primary cold ... Extravascular #Causes #differential
Idiopathic CD4 Lymphopenia (ICL) / Lymphocytopenia DIAGNOSTIC CRITERIA FOR ICL • Persistent CD4 T-cell lymphopenia •
(ICL) / Lymphocytopenia ... DIAGNOSTIC CRITERIA FOR ICL ... Unc119) • Heme (lymphoma ... #Lymphopenia #ICL ... #Differential #
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Rebound effect from treatment ... Metastatic cancer, Lymphoma ... Inflammatory Conditions: Rheumatologic ... Kawasaki, Nephrotic syndrome ... Glucocorticoids, IL
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Disease (CAD): - Idiopathic ... Agglutinin Syndrome ... autoimmune disorder or lymphoid ... - Monoclonal - Lymphoid ... younger pts) Differential
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Marginal Zone Lymphoma ... Marginal zone lymphoma ... Evans • ITP • Cl-NH ... anemia due to cold ... #Monoclonal #Differential
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Incidence: common in APL ... Triggers: ATRA treatment ... initiation • Differential ... organ dysfuxtion, ICU
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
matter, spinal cord ... Behcet disease) Differential ... Ischemia, Leukemia, Lymphoma ... Arthritis, AS Treatment ... signs #symptoms #rheumatology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Cell Leukemia • Idiopathic ... Significance (ICUS) • Idiopathic ... factor (GCSF) treatments ... blood count with differential ... #diagnosis #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
erythematosus (ACLE ... permanent alopecia Differential ... Non-autoimmune rheumatologic ... Angioimmunoblastic T-cell lymphoma ... La, anti-Jo-1, SCL
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
Idiopathic MCD without ... - 30-40 years old ... with interleukin (IL ... Hypoalbuminemia Treatment ... diagnosis #management #rheumatology
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