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causes hyperkalemia nephrology potassium management neurology ammonia apml cardiology comatose differentiation diuresis diuretics druginduced encephalopathy erythematosus excretion fever hematology hyperammonemia
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
• Exogenous (KCL ... #hyperkalemia #differential ... #diagnosis #pathophysiology ... #pharmacology # ... potassium #medications
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Hyperkalemia - Differential ... Diagnosis Framework ... phlebotomy High ... - Tumor lysis syndrome ... Medications 2.
Schematic representation of the major sources of ammonia production and its excretory pathway (GI = gastrointestinal,
ileal conduit - Medications ... rare): - Reye syndrome ... deficiency #Ammonia #Pathophysiology ... Hyperammonemia #Differential ... #Diagnosis
Widened Pulse Pressure - Differential Diagnosis and Pathophysiology Pulse pressure is the difference between the systolic blood
Diagnosis and Pathophysiology ... Hyperdynamic circulation/High ... • Mitchell et al ... Acute Coronary Syndrome ... #Diagnosis #Pathophysiology
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Hyperkalemia - Differential ... Diagnosis Framework ... phlebotomy High ... - Tumor lysis syndrome ... Medications 2.
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Incidence: common in APL ... ATRA treatment Pathophysiology ... • Attempt if high ... initiation • Differential
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
Etiology: • Pathophysiology ... circulation: MCA ACA ... Reversible course Differential ... Diagnosis: • ... Electrolyte abnormality, Medication
Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
• Diagnosis of ... Inhibitors of Na+K+2Cl ... Loop Diuretics; High-Ceiling ... Diuresis #Nephrology #Pharmacology ... #Medications #Table
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
complements and a high ... erythematosus (ACLE ... permanent alopecia Differential ... Diagnosis: • ANCA-associated ... activation and/or medications
The Neurological Evaluation of a Comatose Patient Definition: • Coma: a state of unresponsiveness; the absence of
consciousness Differential ... Diagnosis: • ... • Locked-in syndrome ... • Mutism Pathophysiology ... Anisocoria + Coma → high
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