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diagnosis symptoms potassium 21hydroxylasedeficiency 21ohd benzodiazepine bzd diabetes diabeticketoacidosis differential dka druginduced genetics glftap hematology hyperthyroid hyperthyroidism hypothyroidism impaired leukostasis
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
of Drug-Induced Hyperkalemia ... • Exogenous (KCL ... MunerMohamed1 #hyperkalemia ... differential #diagnosis #pathophysiology ... #pharmacology #
Hypothyroid Myopathy Very common (up to 80% ) in patients with hypothyroidism Pathophysiology: • T4 deficiency leads to
Hypothyroid Myopathy ... hypothyroidism Pathophysiology ... #Myopathy #pathophysiology ... #signs #symptoms ... #endocrinology
Drugs that Impair Renal Potassium Excretion Decreased ENaC channel function: Amiloride, Triamterene, Pentamidine Decreased Aldosterone Synthesis: Heparin,
Aldosterone Release: ACE ... happypillsrx/ #Hyperkalemia ... #Pathophysiology ... #Pharmacology #
Hypothyroidism and Hyperthyroidism - Symptoms and Signs Hypothyroidism: - General - From asymptomatic to myxedema coma, “Like
- Symptoms and Signs ... running a marathon all ... #Hyperthyroid # ... Symptoms #Signs ... #Diagnosis #endocrinology
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
wasting crisis & hyperkalemia ... Signs/Symptoms/Complications ... : • Hyperkalemia ... #21HydroxylaseDeficiency #21OHD #pathophysiology ... #genetics #endocrinology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... have fever - ACS ... WBC >100k, + lab signs ... Lysis Syndrome: • Pathophysiology ... hydration - Hyperkalemia
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings • Note: in DKA, body K+ is lost
To prevent hypokalemia ... Signs/Symptoms/Complications ... DiabeticKetoacidosis #DKA #pathophysiology ... #endocrinology
Pituitary Mass Effects - Pathogenesis and Clinical Findings • Pituitary turnors are almost always a benign
pituitary masses of all ... Signs / Symptoms ... #SideEffects #endocrinology ... mnemonic #GLFTAP #pathophysiology
Benzodiazepine (BZD) withdrawal: clinical findings and complications • Activation of ACC and OFC -> Feelings of
Activation of ACC ... BZD #withdrawal #pharmacology ... #pathophysiology ... #diagnosis #signs
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