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management rheumatology syndrome oncology 1 aclf activation acute adultonset algorithm apml arteritis cancer cap cdi cdiff chronic cirrhosis classification clostridioides
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Liver Failure (ACLF ... ) Clinical Guidelines ... ACLF = possibly ... EmoryGastroHep #ACLF ... #gastroenterology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Incidence: common in APL ... Triggers: ATRA treatment ... - pulmonary opacities ... unless severe APLS ... #management #hematology
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... Disease Clinical ... hepatitis • Pulmonary ... #management #treatment ... #rheumatology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
, dyspnea, +/- CXR ... have fever - ACS ... organ damage • Treatment ... Syndrome #TLS #diagnosis ... #management #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Assessment • Clinical ... Purtilo (XLP) Acquired ... diseases: SLE+++, Adult-onset ... #management #treatment
TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
Risk factors: Critical ... fluid balance, and CXR ... with pulmonary ... Transfusion #Reactions #hematology ... #diagnosis #comparison
Community Acquired Pneumonia (CAP) - Diagnosis and Management Pneumonia Signs/Symptoms: • Confusion/disorientation (LR + 1.9) • Cough
Community Acquired ... Pneumonia (CAP) - Diagnosis ... be initiated in adults ... with clinically ... #Pulmonary #Community
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
the secondary or acquired ... arthritis (sJIA) • Adult-onset ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis ... #Management #Hematology
C.diff - Clostridioides Difficile Infection (CDI) - Diagnosis and Management - GrepMed Handbook Clinical Presentation + Progression:
GrepMed Handbook Clinical ... can be community-acquired ... - produced by all ... #management #treatment ... infectiousdiseases #IDSA #gastroenterology
5-Oxoprolinuria What is it: • Aka pyroglutamic acidosis, Intermediate in γ-glutamyl cycle • Amino acid transport and
oxoprolinase • Acquired ... disease in adults ... high index of clinical ... (all empirical ... #management #treatment
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