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differential hematology allergy causes allergic definitions management abpa anemia aspergillosis basophilia basophils blood bronchopulmonary clinicopathology conjugated disorders eosinophil eosinophilia hemolytic
Types of hypersensitivity reactions Type I - lgE-Mediated, Within I Hour (Anaphylaxis) Type II - IgG or IgM
Types of hypersensitivity ... reactions Type ... #reactions #Types ... #Classification ... #Allergy #Diagnosis
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
Penicillin-induced drug reaction ... Dermatitis (ie. reaction ... Allergy #Allergic #Reactions ... #Types #Classification ... #Diagnosis #Definitions
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
Hypersensitivity ... or during hemolytic ... #Types #Classification ... Pathophysiology #Allergy #Diagnosis ... #Reactions #Table
Vesiculobullous Skin Rash - Differential Diagnosis Algorithm Vesicles Fragile/EasiIy Ruptured - Intraepidermal blisters, possibly crusts/erosions - Inflammatory
- Differential Diagnosis ... Algorithm Vesicles ... to Agent ... to Agent ... Vesiculobullous #SkinRash #dermatology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... Malaria • Oxygen agents ... • Transfusion reactions ... #causes #classification ... #hematology
Hypersensitivity: Definitions • Type I - Production of lgE Abs that bind to harmless allergens and
Hypersensitivity ... Definitions • Type ... #Hypersensitivity ... #Types #Classification ... #Diagnosis #Definitions
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
- Differential Diagnosis ... Algorithm Peripheral ... myelosuppressive agents ... #Differential #Diagnosis ... #Algorithm #hematology
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
- Differential Diagnosis ... which are released during ... an allergic reaction ... basophilic leukemia Hypersensitivity ... #causes #hematology
Allergic Bronchopulmonary Aspergillosis (ABPA) WHAT IS IT? Hypersensitivity response to Aspergillus fumigatus in the airways • Primarily affects
Hypersensitivity ... • Immediate type-skin ... reaction to Aspergillus ... with an azole agent ... ABPA #pulmonary #diagnosis
Classification of Jaundice Unconjugated hyperbilirubinemia (predominantly indirect bilirubin) • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
Classification of ... syndrome, drug reactions ... or mutation in genes ... coding for bile ... #diagnosis #conjugated
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