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Algorithm for evaluation of elevated serum alkaline phosphatase.

#Algorithm #elevated #alkaline #phosphatase #AlkPhos #Elevation #Diagnosis #workup
elevated serum alkaline ... phosphatase. ... Algorithm #elevated #alkaline ... #phosphatase #AlkPhos
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
Alkaline Phosphatase ... Bone growth) Alkaline ... phosphatase sources ... stricture/Stones #Alkaline ... #Phosphatase #ALP
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Low Alkaline Phosphatase ... Hypophosphatasia Is Low Alkaline ... Symptoms of Low Alkaline ... Diagnosis of Low Alkaline ... urinary PEA #Low #Alkaline
Liver Function Tests (LFTs)
 - Aspartate aminotransferase (AST) 
 - Alanine aminotransferase (ALT) 
 - Alkaline
aminotransferase (AST) - Alanine ... aminotransferase (ALT) - Alkaline ... phosphatase
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury
Hepatocellular Liver Injury
 • AST/ALT elevation
+ ULN ALT) / (alkaline ... phosphatase + ULN ... alkaline phosphatase
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
Transaminase >> Alkaline ... Phosphatase, ALT ... Cholestatic Pattern - Alkaline ... Phosphatase >>
Pathologic / Fragility Fractures - Differential Diagnosis Algorithm 
Tumours
 - See Bone Lesions Scheme
Paget's Disease
 -
Pelvis - Positive Alkaline ... Phosphatase Renal ... Mineralization Defect • Phosphate
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
compared with alkaline ... phosphatase) 2 ... disproportionate increase in alkaline ... phosphate compared
Urine Microscopy Crystals
Uric Acid crystals:
 - Formation promoted by acidic urine
 - Seen in tumor lysis
syndrome Calcium phosphate ... Formation promoted by alkaline ... Magnesium ammonium phosphate ... struvite or "triple phosphate ... Formation promoted by alkaline
Impact and Challenges With Vitamin D to Treat Secondary Hyperparathyroidism in Patients With Chronic Kidney Disease
bone-specific alkaline ... phosphatase and ... bone-specific alkaline ... phosphatase and