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diagnosis differential hematology algorithm lupus sle acidosis activation agitation antibiogram antibiotics aplastic cardiology chronic classification criticalcare delirium dermatology elevatedmcv elevation
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Megakaryopoiesis • Aplastic Anemia ... methotrexate) • Drugs ... Non-lmmune: • HELLP Syndrome ... #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... ) - HELLP syndrome ... Hemolytic uremic syndrome ... infection) - Drugs ... #anemia
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Blood Smear • Drugs ... Increased Requirement (e.g ... Myelodysplastic Syndromes ... #Hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
and petechiae Causes ... - Cytotoxic drugs ... - Antithyroid medications ... #oncology #hematology ... #diagnosis #management
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Causes of Fatigue ... Hematologic • Anemia ... Myasthenia Gravis Pharmacologic ... Abuse (e.g. ... Chronic Fatigue Syndrome
Hydroxychloroquine Serum Measurement in SLE • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
200ng/mL Best indications ... (e.g. renal failure ... Measurement #SLE #rheumatology ... #pharmacology # ... levels #lupus #management
Causes of Acute Pericarditis: Infectious; Viral: Adenovirus Coxsackie virus A and B Echovirus Epstein-Barr virus Hepatitis Human immunodeficiency
Causes of Acute ... - related Medication ... induced (select drugs ... pericarditis) Uremia ... Rheumatic fever #Causes
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 Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
• Infection (eg ... ) • Sepsis • Drug-induced ... with leukopenia, anemia ... #Diagnosis #Management ... #Hematology #Rheumatology
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
circulation If drugs ... - Compartment syndrome ... 30mmHg) - Severe anemia ... Alcohol • Type B2: Drugs ... - HIV/HAART medications
Causes of Neutropenia - Differential Diagnosis Neonate: - Infection - by far the most common cause -
Constitutional disorders, eg ... neutropenia, Kostmann syndrome ... Chediak-Higashi syndrome ... Megaloblastic anemia-rare ... #hematology
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