22 results
diagnosis differential hematology treatment lupus neurology algorithm elevation erythematosus hemophagocytic hlh lymphohistiocytosis summary systemic acidosis agitation anemia antibiogram antibiotics antiil6
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... methotrexate) • Drugs ... Autoimmune • ITP • SLE ... Non-lmmune: • HELLP Syndrome ... #Hematology
Hydroxychloroquine Serum Measurement in SLE • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
Measurement in SLE ... (e.g. renal failure ... #rheumatology # ... pharmacology #levels ... #lupus #management
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Causes of Fatigue ... Arthritis • SLE ... Myasthenia Gravis Pharmacologic ... Abuse (e.g. ... Chronic Fatigue Syndrome
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... erythematosus [SLE ... ) • Sepsis • Drug-induced ... #Management #Hematology ... #Rheumatology
Vasopressors and Inotropes - Pharmacology Summary Vasopressors Phenylephrine (alpha-1) • Increases BP, SVR • Risk of reflex bradycardia
and Inotropes - Pharmacology ... • Higher doses cause ... dependent receptor activation ... #Summary #management ... #medications
Anti-IL6 Agents (Tocilizumab, Siltuximab) in COVID19 IL-6 activates T cells and macrophages, among other cell types (see
other cell types (see ... “Cytokine Activation ... Syndrome” IL-6 ... Siltuximab #COVID19 #Pharmacology ... #Management #Medications
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... Autoimmune diseases: SLE ... immune deficiency, Drugs ... Lymphohistiocytosis #diagnosis #management ... treatment #summary #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... Demyelinating Syndrome ... autoantibodies that will cause ... CNS #neurology #rheumatology ... cerebritis #diagnosis #management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Non-autoimmune rheumatologic ... extremities Drug ... • Antihistone: Drug ... Chronic B-cell activation ... and/or medications
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
and petechiae Causes ... Dyskeratosis congenita • Drugs ... - Cytotoxic drugs ... - Antithyroid medications ... #diagnosis #management
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