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diagnosis signs management msk sle 21hydroxylasedeficiency 21ohd alcohol bulimianervosa caudaequina chronic diabetes diabeticketoacidosis dka erythematosus essential et etoh genetics glftap
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... Myopathy (Also caused ... Musculoskeletal #Complications ... #pathophysiology ... #signs #symptoms
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
hair follicles -> causes ... keratinocytes but abnormal ... Manifestations #pathophysiology ... diagnosis #signs #symptoms ... #complications
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings • Note: in DKA, body K+ is lost
out of cells may cause ... to be falsely normal ... Signs/Symptoms/Complications ... DiabeticKetoacidosis #DKA #pathophysiology ... #endocrinology
Cauda Equina Syndrome Causes: • Large lumbar degenerative disc herniation (central) • Severe lumbar spondylosis • Neoplasm
Equina Syndrome Causes ... spine Signs / Symptoms ... / Complications ... Areflexia (loss of normal ... Syndrome #MSK #pathophysiology
Chronic Hypertensive Retinopathy: Pathogenesis and clinical findings Ophthalmic Artery Hypertension Stage 1: Mild/vasoconstrictive • Acute and chronic vasospasm
hyalinization causes ... dot/blot hemorrhages ... #Retinopathy #pathophysiology ... diagnosis #signs #symptoms ... #complications
Pituitary Mass Effects - Pathogenesis and Clinical Findings • Pituitary turnors are almost always a benign
For pituitary masses ... Signs / Symptoms ... / Complications ... #SideEffects #endocrinology ... mnemonic #GLFTAP #pathophysiology
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
enzyme 21-OHase causes ... Signs/Symptoms/Complications ... #21HydroxylaseDeficiency #21OHD #pathophysiology ... #genetics #endocrinology
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
survival is 93-95% Pathophysiology ... are not caused ... patients have no symptoms ... skin (16-32%): lupus ... ), liver (pain/abnormal
Paget’s Disease: Complications Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation MSK
Paget’s Disease: Complications ... cause excessive ... PagetsDisease #pathophysiology ... diagnosis #signs #symptoms ... #complications
Bulimia Nervosa: Signs and Symptoms Associated Psychological / Behavioural Features • Feelings of shame, guilt and embarrassment
Nervosa: Signs and Symptoms ... related to complications ... , amenorrhea, Normal ... Sores, scars, calluses ... BulimiaNervosa #pathophysiology
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