10 results
Oral anticoagulant dosing and bridging for VTE

- Dr. Joseph Shatzel @Clotmaster 

#VTE #DOAC #Bridging #Dosing #Oral
Oral anticoagulant ... #Anticoagulation ... #Dabigatran #Apixaban ... #Rivaroxaban #Edoxaban ... #Loading #DVT #Pharmacology
Oral Anticoagulation Management Cheat Sheet: Warfarin, Apixaban, Dabigatran, Rivaroxaban
 - Mechanism of Action
 - Routine Blood
Oral Anticoagulation ... Sheet: Warfarin, Apixaban ... #Anticoagulation ... Management #Table #Pharmacology ... #Stop #Perioperative
DOAC Cheat Sheet
 • Apixaban, Dabigatran, Edoxaban, Rivaroxaban
 • Renal Dosing
 • Common Drug interactions
 •
Cheat Sheet • Apixaban ... , Dabigatran, Edoxaban ... Bloodman #DOAC #anticoagulation ... #CheatSheet #dosing ... #ckd #pharmacology
Pharmacokinetic Characteristics and Primary Routes of Clearance of Oral Anticoagulant Agents

Warfarin - 100% Hepatic, 0% Renal
Apixaban
of Clearance of Oral ... Hepatic, 0% Renal Apixaban ... Hepatic, 80% Renal Edoxaban ... NOAC #Metabolism #Pharmacology ... #anticoagulation
Xa Inhibitors - Apixaban and Rivaroxaban 
Oral Xa inhibitors are recommended by CHEST as first-line for
Rivaroxaban Oral ... Fibrillation requiring anticoagulation ... indications and edoxaban ... overview of the dosing ... #Pharmacology
DOAC: Cheat Sheet - Atrial Fibrillation, VTE Prophylaxis, VTE and Renal Dosing

Renal Dosing:
Apixaban (25% renal clearance):
: Apixaban (25% ... if CrCl < 50) Edoxaban ... OralAnticoagulant #Anticoagulation ... #Hematology #Pharmacology ... #Dabigatran #Edoxaban
Choice of anticoagulant for treatment of pulmonary embolism
 • Malignancy - LMWH
 • To avoid parenteral
- Rivaroxaban; apixaban ... • Once a day oral ... - Rivaroxaban; edoxaban ... decisionaid #vte #anticoagulation ... #pharmacology
Perioperative Management of DOACs
Problem:
 ✖ Each year approximately 250,000 patients on chronic anticoagulation in North America
Perioperative Management ... direct acting oral ... inhibitor) • Apixaban ... , Edoxaban, Rivaroxaban ... Management #Treatment #pharmacology
DOAC Reversal
Emergency surgery or urgent procedure
Stop anticoagulant treatment; volume resuscitation and transfusion as needed
Antidotes:
 • Apixaban,
transfusion as needed Antidotes ... : • Apixaban, Edoxaban ... concentrate - If antidotes ... Reversal #NOAC #Oral ... hematology #management #pharmacology
Warfarin to DOAC and DOAC to Warfarin Transitions 

Here are a couple of charts to help
DOACs for easier dosing ... Quick tip: apixaban ... Edoxaban is <2.5 ... Transitioning #Anticoagulation ... #Pharmacology #