8 results
Oral anticoagulant dosing and bridging for VTE

- Dr. Joseph Shatzel @Clotmaster 

#VTE #DOAC #Bridging #Dosing #Oral
Oral anticoagulant ... #Anticoagulation ... #Dabigatran #Apixaban ... #Loading #DVT #Pharmacology ... #Hematology
DOAC: Cheat Sheet - Atrial Fibrillation, VTE Prophylaxis, VTE and Renal Dosing

Renal Dosing:
Apixaban (25% renal clearance):
Renal Dosing ... patients 5mg bid Dabigatran ... OralAnticoagulant #Anticoagulation ... #Hematology #Pharmacology ... #Rivaroxaban #Dabigatran
Managing warfarin INR

Warfarin dosage must be individualized according to the patient's response to the drug, and
Over-anticoagulation ... management #algorithm #pharmacology ... #treatment #medications ... decisionaid #cardiology #hematology ... #warfarin #dosing
DOAC Reversal
Emergency surgery or urgent procedure
Stop anticoagulant treatment; volume resuscitation and transfusion as needed
Antidotes:
 • Apixaban,
modified factor Xa • Dabigatran ... concentrate - If antidotes ... Reversal #NOAC #Oral ... anticoagulant #hematology ... #management #pharmacology
Xa Inhibitors - Apixaban and Rivaroxaban 
Oral Xa inhibitors are recommended by CHEST as first-line for
Rivaroxaban Oral ... Fibrillation requiring anticoagulation ... approved for these indications ... overview of the dosing ... #Pharmacology
Perioperative Management of DOACs
Problem:
 ✖ Each year approximately 250,000 patients on chronic anticoagulation in North America
patients on chronic anticoagulation ... direct acting oral ... clearance (calculated using ... of Therapy • Dabigatran ... Management #Treatment #pharmacology
Rybelsus (oral semaglutide) - First Oral GLP-1 Agonist
Dosing:
3 mg daily x 30 days, then 7 mg
-1 Agonist Dosing ... semaglutide, the same medication ... take any other medications ... been shown non-inferior ... semaglutide #Diabetes #Pharmacology
Medications to Avoid in Patients with G6PD Deficiency Due to Risk of Hemolysis
 - Chloroquine (Aralen)*
Medications to Avoid ... (Non-steroidal Oral ... Methylene Blue) - Antidote ... Differential #Diagnosis #Pharmacology ... #Hematology