10 results
Coagulation Cascade and Anticoagulant Sites of Action

- Amy Chung, MD, MSc https://twitter.com/AmyChung

#AntiCoagulation #Cascade #Anticoagulants #Medications #Pharmacology
Anticoagulants #Medications ... #Pharmacology # ... Pathophysiology #Mechanisms #DOAC ... #Hematology
DOAC Reversal
Emergency surgery or urgent procedure
Stop anticoagulant treatment; volume resuscitation and transfusion as needed
Antidotes:
 • Apixaban,
transfusion as needed Antidotes ... concentrate - If antidotes ... not available #DOAC ... anticoagulant #hematology ... #management #pharmacology
Summary of Coagulation Deficiencies
Inherited:
 • Hemophilia A - Deficiency of Factor VIII
 • Hemophilia B -
malnutrition, Antibiotics ... Anticoagulant Medications ... LMWH, warfarin, DOACs ... comparison #diagnosis #hematology
Tranexamic Acid - Indications and Pharmacology
Pharmacokinetics:
 • MOA: Inhibits plasminogen activation to plasmin & inhibits fibrinolysis
Tranexamic Acid - Indications ... and Pharmacology ... : Urine Common Uses ... #Pharmacology # ... hematology
Causes of Isolated Neutropenia - Differential Diagnosis Algorithm
Congenital
Medications
 • Anticonvulsants
 • Antibiotics
 • Antithyroid
 • Antihypertensive
Causes of Isolated ... Algorithm Congenital Medications ... Anticonvulsants • Antibiotics ... Diagnosis #Algorithm #Causes ... #Hematology
Drug Induced Uveitis - Medications Associated with Uveitis

#DrugInduced #Uveitis #Medications #Rheumatology #Pharmacology #Differential #Causes
Induced Uveitis - Medications ... DrugInduced #Uveitis #Medications ... #Rheumatology # ... Pharmacology #Differential ... #Causes
Hydroxychloroquine Serum Measurement in SLE
 • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
200ng/mL Best indications ... suspected) • In case ... • Special cases ... Measurement #SLE #rheumatology ... #pharmacology #
Medications to Avoid in Patients with G6PD Deficiency Due to Risk of Hemolysis
 - Chloroquine (Aralen)*
Medications to Avoid ... Methylene Blue) - Antidote ... Macrodantin)* - Antibiotic ... Differential #Diagnosis #Pharmacology ... #Hematology
Hydroxychloroquine - Risks and Benefits in Lupus
Benefits:
↓ Disease activity, ↓ Flare, ↓ Damage, ↓ Corticosteroid dose,
Digestive intolerance nausea ... recommended with other medications ... rare with ~100 cases ... Benefits #Lupus #pharmacology ... #sideeffects #rheumatology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
and petechiae Causes ... - Antithyroid medications ... - β-lactam antibiotics ... Anemia #oncology #hematology